Chemical Biology Program
The Arvin Dar Lab
Research
The Dar laboratory explores cancer mechanisms and new approaches in chemical biology. Our research integrates genetics, biochemistry, structure, and small molecule discovery. Our primary goal is to develop tools that enable us to modulate cell signaling networks, allowing for in-depth mechanistic exploration of disease and potential therapeutic applications.
In our previous work, we successfully designed chemical switches and conformational modulators that selectively bind to specific targets of interest. By manipulating the conformational equilibrium, we can effectively influence the formation of specific states or complexes. Another area of research has been on molecular glues that operate at the interface of biomolecular complexes to regulate the assembly, lifetime, and fate of signal transduction events.
Overall, we are focused on the development of chemical tools and probes to target cancers driven by dysregulated enzymes, receptors, cellular communication pathways, and the tumor microenvironment.
Research Projects
Publications
Rialdi A., Duffy M, Scopton, A, Zhao J, Schwarz M, Ruiz de Galarreta M, Lim YT, Molina-Sanchez P, Rosemann F, Khan Z, Lakshmananm M, Tan SY, Jin J, Villanueva A, Michailidis E, De Jong YP, Rice CM, Sobota RM, Lujambio A*, Guccione E*, and Dar A.C.*. A kinase inhibitor with specificity against b-catenin mutant hepatocelllular carcinoma generated through reduced anti-target engagement. Nature Cancer. 2023, In press.
People
Arvin Dar, PhD
- Arvin Dar’s lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets.
- University of Toronto
- [email protected]
- Email Address
- 212-639-8825
- Office Phone
Members
Lab Affiliations
Achievements
- Mark Foundation for Cancer Research ASPIRE Award
- Friedman Brain Institute Scholar
- Pershing Square Sohn Prize for Young Investigators (PSSCRA)
- Pew-Stewart Scholars for Cancer Research (Pew Foundation)
- Damon Runyon-Rachleff Innovation Award
Read more
- NIH Director’s New Innovator Award
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
-
Lab Head Email
-
Office Phone